I say with all of the compassion and love possible to please get a second opinion at a Cancer Center hospital. The first doctors you visited may not have done all of the right things or not explained things well. But please go to another place. Preferably a true cancer center, not a general hospital or doctor. Advocate for your wife and demand clear, understandable explanations or what is wrong, what the treatment plan is, and why.
I have honestly lost a friend to Breast Cancer due to the types of treatments recommended here. Please see a trained physician and be a strong advocate. I pray for the healing of your wife.