Re: Detoxifying acetaldahyde

The Comparative Toxicogenomics Database (CTD) is a public resource that promotes understanding about the interaction of environmental chemicals with gene products, and their effects on human health. This wealth of expanded chemical-gene-disease data continues to help users generate testable hypotheses about the molecular mechanisms of environmental diseases [1].

If there is any lingering doubt about the ability of acetaldehyde to precipitate and participate in disease processes, check out the more than one thousand cross-indexed entries between "Acetaldehyde and Disease" listed in the reference:

http://ctdbase.org/detail.go?type=chem&acc=D000079&view=disease

To make matters even worse, the "pulsed low dosage" exposure profile of acetaldehyde emission from Candida Albicans may be inducing a tolerance to acetaldehyde. This means that the normal acetaldehyde scavenging and neutralization mechanisms may not be responding adequately to its presence, thus increasing its downstream toxicity potential [2].

[1] Davis AP et al., "The Comparative Toxicogenomics Database: update 2011.", Nucleic Acids Res. 2011 Jan;39(Database issue):D1067-72. Epub 2010 Sep 22.
http://www.ncbi.nlm.nih.gov/pubmed/20864448

[2] Crouch JY et al., "Inhibition of rat liver transaminases by low levels of acetaldehyde and the pharmacologic effects of B6 vitamers.", Biochem Pharmacol. 1989 Oct 15;38(20):3431-7.
http://www.ncbi.nlm.nih.gov/pubmed/2818634