All that is needed is to kill the microbes

From Wikipedia:

"In the parasitic filarial nematode species responsible for elephantiasis, such as Brugia malayi and Wuchereria bancrofti, Wolbachia has become an obligate endosymbiont and provides the host with chemicals necessary to its reproduction and survival.[29] Elimination of the Wolbachia symbionts ... therefore prevent reproduction of the nematode, and eventually results in its death."

All that is needed is to kill the microbes.