I had my gall bladder removed last year and have completely 13 successful flushes. As for an answer to your question... Yes, I have gotten stones out as big as marbles. In fact most of my stones are as big as marbles and in fact some are much bigger. One stone (on my 6-7?) flush was the size of a golf ball. But I am still working on things. I know I have a ways to go yet. In total I have flushed at least 1200 stones- and I'm at it again tonight. Keep on the good work!