These by themselves would kill and pull out any worms in your colon and would probably be best done just before going to bed. I didn't expel any worms when my naturopath prescribed them to me because I probably didn't have any, her major suspicion was that I had candida overgrowth anyway, because I had a mouthfull of amalgam fillings. The way she told me to make it was to first boil 5 cups of bottled water for 10 mins., then add 6 large cloves of garlic grated, cover the pot and let the water cool to a comfortable warmth, then strain the solution before putting it into the enema bag.